• Yingbin Fu, PhD

    Assistant Professor, Department of Opthalmology & Visual Sciences, John A. Moran Eye Center, University of Utah

    Research: “Mechanisms and Treatment Strategies for Leber Congenital Amaurosis”


    • Image-forming vision in vertebrates
    • Assembly and trafficking of photoreceptor proteins
    • Genetic variants of age-related macular degeneration


    Jones A, Kumar S, Zhang N, Tong Z, Yang J-H, Watt C, Anderson J, Fnu A, Fillerup H, Mccloskey M, Luo L, Yang Z, Ambati B, Marc R, Oka C, Zhang K, and Fu Y (2011). Increased expression of multifunctional serine protease, HTRA1, in retinal pigment epithelium induces polypoidal choroidal vasculopathy in mice. Proc Natl Acad Sci U S A. Aug 15.

    Zhang T, Zhang N, Baehr W, Fu Y (2011). Cone opsin determines the time course of cone photoreceptor degeneration in Leber congenital amaurosis. Proc Natl Acad Sci U S A.

    Fu, Y. (2010) Phototransduction: Phototransduction in Rods. In Encyclopedia of the Eye. Edited by Besharse, J., Dana, R. & Dartt, D. A. Elsevier Academic Press. Volume 3, pp. 397-402.

    Yang Z, Tong Z, Chen Y, Zeng J, Sun X, Zhao C, Davey L, Wang K, Chen H, London N, Muramatsu D, Salasar F, Kasuga D, Wang X, Dixie M, Zhao P, Yang R, Gibbs D, Lu F, Liu X, Li Y, Li B, Li C, Li Y, Campochiaro B, Constantine R, Zack D, Campochiaro P, Fu Y, Li D, Katsanis N, and Zhang K. (2010). Genetic and functional dissection of HTRA1 and LOC387715 in age-related macular degeneration. PLoS Genet 6, e1000836.

    Fu, Y, Kefalov, V, Luo, DG, Xie, T, Yau, KW. (2008) Quantal noise from human red cone pigment. Nature Neuroscience. 11: 565-571

    Fu, Y. and Yau, K. W. (2007) Phototransduction in mouse rods and cones. Pflugers Arch. – Eur J of Physiol. 454:805-819.

    Imai, H., Kefalov, V., Sakurai, K., Chisaka, O., Ueda, Y., Onishi, A., Morizumi, T., Fu, Y., Ichikawa, K., Nakatani, K., et al. (2007). Molecular properties of rhodopsin and rod function. J Biol Chem. 282:6677-6684.

    Fu, Y., Zhong, H., Wang, M. H., Luo, D. G., Liao, H. W., Maeda, H., Hattar, S., Frishman, L. J., Yau, K. W. (2005) Intrinsically photosensitive retinal ganglion cells detect light with a vitamin A-based photopigment, melanopsin. Proc Natl Acad Sci U S A. 102(29):10339-10244.

    Fu, Y., Liao, H. W., Do, M. T., Yau, K. W. (2005) Non-image-forming ocular photoreception in vertebrates. Curr Opin Neurobiol. 15(4):415-22

Copyright ©2011 E. Matilda Ziegler Foundation for the Blind